R-(-)-gossypol acetic acid

R-(-)-醋酸棉酚

Report date: 2025/05/26 20:01:03
NME

Base Information

Drug NameR-(-)-gossypol acetic acid
Drug Alias NameR-(-)-棉酚(-)-gossypol,Bcl-2/xL inhibitor - 3SBio(-)-gossypolBcl-2/xL inhibitor(3SBio)AT-101 +[7] 
ClassificationNatural product/ExtractSmall molecules > Heterocyclic drugs
Mechanisms of ActionApoptosis regulator Bcl-2 inhibitorsApoptosis regulator Bcl-X inhibitorsInduced myeloid leukemia cell differentiation protein Mcl-1 inhibitors
TargetsApoptosis regulator Bcl-2Apoptosis regulator Bcl-XInduced myeloid leukemia cell differentiation protein Mcl-1
Therapy Area/IndicationsCNS Embryonal TumorHormone-Resistant Prostate NeoplasmsSolid tumours +[28] 
Global Approved IndicationsN/A
Approved Indications in ChinaN/A
Original Approved Country/TerritoryN/A
Original Approved DateN/A
Country/TerritoryUnited StatesUkraineRussian Federation +[4] 
CombinationsNo
Global Highest StatusPhase 2 Clinical
Highest Status in ChinaDiscontinued
Originator CompaniesJiangsu Ascentage Pharma Co LtdUniversity Of Michigan
China Registration ClassClass 1 Chemical Drug in China

Develop Information

Active CompaniesUniversity Of Michigan Rogel Cancer Center
Inactive CompaniesNational Cancer InstituteAscenta Therapeutics IncUniversity Of Alabama At Birmingham +[4] 
Active IndicationsLaryngeal Neoplasms
Inactive IndicationsCNS Embryonal TumorHormone-Resistant Prostate NeoplasmsSolid tumours +[27] 

Other Information

ATC CodeN/A
Related LinksN/A