Nitisinone

尼替西农

Report date: 2025/06/26 17:09:48
NMEFirst In Class

Base Information

Drug NameNitisinone
Drug Alias NameNitisinonaNitisinonumNityrOrfadinHARLIKU +[8] 
ClassificationSmall molecules > Heterocyclic drugs
Mechanisms of Action4-hydroxyphenylpyruvate dioxygenase inhibitors
Targets4-hydroxyphenylpyruvate dioxygenase
Therapy Area/IndicationsAlkaptonuriaAlbinismBlindness +[4] 
Global Approved IndicationsTyrosinemias
Approved Indications in ChinaTyrosinemias
Original Approved Country/TerritoryUnited States
Original Approved Date2002/01/18
Country/TerritoryBelgiumUnited StatesSweden +[12] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaApproved
Originator CompaniesSwedish Orphan Biovitrum Ag
China Registration ClassN/A

Develop Information

Active CompaniesSwedish Orphan Biovitrum AgCycle Pharmaceuticals LtdAstellas Pharma Inc +[7] 
Inactive CompaniesSwedish Orphan Biovitrum (Sobi)University Of LiverpoolUniversity Of California San Diego +[6] 
Active IndicationsAlkaptonuriaTyrosinemias
Inactive IndicationsAlbinismBlindness

Other Information

ATC CodeA16AX04
Related LinksWikipediaDrugBankKEGG