Vorasidenib

伏昔尼布

Report date: 2026/05/09 20:00:18
NME

Base Information

Drug NameVorasidenib
Drug Alias NameVorasidenib citrateVORANIGOAG-881AGI-23088S-95032 +[6] 
ClassificationSmall molecules > Heterocyclic drugs
Mechanisms of ActionIsocitrate dehydrogenase [NADP], mitochondrial inhibitorsIsocitrate dehydrogenase [NADP] cytoplasmic inhibitors
TargetsIsocitrate dehydrogenase [NADP] cytoplasmicIsocitrate dehydrogenase [NADP], mitochondrial
Therapy Area/IndicationsLiver DysfunctionMyelodysplastic SyndromesHepatic Insufficiency +[11] 
Global Approved IndicationsOligodendrogliomaGangliogliomaAstrocytoma +[4] 
Approved Indications in ChinaN/A
Original Approved Country/TerritoryUnited States
Original Approved Date2024/08/06
Country/TerritoryMainland China(BOAO LECHENG)CzechiaBelgium +[18] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaNDA/BLA
Originator CompaniesAgios Pharmaceuticals Inc
China Registration ClassN/A

Develop Information

Active CompaniesInstitut De Recherches Internationales Servier Iris SarlServier Bio-Innovation LLCRoyalty Pharma +[13] 
Inactive CompaniesAgios Pharmaceuticals Inc
Active IndicationsLiver DysfunctionHepatic InsufficiencyLiver Diseases +[8] 
Inactive IndicationsMyelodysplastic SyndromesHematologic NeoplasmsLeukemia, Myeloid, Acute

Other Information

ATC CodeN/A
Related LinksWikipediaDrugBankKEGG