engineered variant domain fusion protein program (Alpine Biosciences)

N/A

Report date: 2025/06/11 11:17:28

Base Information

Drug Nameengineered variant domain fusion protein program (Alpine Biosciences)

Drug Alias Namedual CD28 costimulator/PD-L1 checkpoint inhibitor (Alpine Immune Sciences)dual CD28 costimulator/HHLA-2 checkpoint inhibitor (Alpine Immune Sciences)PD1-CD86TMGD2-CD28

ClassificationBiologics > Protein drugs > Recombinant protein > Fusion proteinBiologics > Protein drugs > Immunoglobulin > Antibody

Mechanisms of ActionT lymphocytes stimulantsHERV-H LTR-associating protein 2 inhibitorsImmunostimulants +[5]

TargetsProgrammed death-ligand 1T-cell-specific surface glycoprotein CD28HERV-H LTR-associating protein 2

Therapy Area/IndicationsNeoplasms

Global Approved IndicationsN/A

Approved Indications in ChinaN/A

Original Approved Country/TerritoryN/A

Original Approved DateN/A

Country/TerritoryUnited States

CombinationsNo

Global Highest StatusPreclinical

Highest Status in ChinaN/A

Originator CompaniesAlpine Immune Sciences Inc

China Registration ClassN/A

Develop Information

Active CompaniesAlpine Immune Sciences Inc

Inactive CompaniesN/A

Active IndicationsNeoplasms

Inactive IndicationsN/A

Other Information

ATC CodeN/A