Methylnaltrexone Bromide

溴化甲基纳曲酮

Report date: 2026/05/20 20:02:01
NME

Base Information

Drug NameMethylnaltrexone Bromide
Drug Alias Name溴甲钠曲酮N-methylnaltrexone bromide甲纳曲酮溴铵methylnaltrexoni bromidumbromuro de metilnaltrexona +[12] 
ClassificationSmall molecules > Heterocyclic drugs
Mechanisms of ActionMu opioid receptor antagonists
TargetsMu opioid receptor
Therapy Area/IndicationsLiver DysfunctionOpioid-Related DisordersOpioid-Induced Constipation +[11] 
Global Approved IndicationsOpioid-Related DisordersOpioid-Induced ConstipationConstipation
Approved Indications in ChinaN/A
Original Approved Country/TerritoryCanada
Original Approved Date2008/03/28
Country/TerritoryBelgiumCanadaUnited States +[17] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaPhase 1 Clinical
Originator CompaniesProgenics Pharmaceuticals Inc
China Registration ClassN/A

Develop Information

Active CompaniesBausch Health Ireland LtdSalix PharmaceuticalsYichang Humanwell Pharmaceutical Co Ltd +[4] 
Inactive CompaniesUniversity of ZurichSt. John Health System IncThe Ohio State University +[5] 
Active IndicationsOpioid-Related DisordersOpioid-Induced ConstipationConstipation +[4] 
Inactive IndicationsLiver DysfunctionPostoperative ComplicationsRenal Insufficiency +[7] 

Other Information

ATC CodeA06AH01
Related LinksWikipediaDrugBankKEGG