Topiramate

托吡酯

Report date: 2026/04/22 20:01:10
NME

Base Information

Drug NameTopiramate
Drug Alias Name妥比那梅TopiramatumTopimax MigraineEpitomaxTopiramato +[18] 
ClassificationSmall molecules > Heterocyclic drugs
Mechanisms of ActionGlutamate receptor ionotropic AMPA antagonistsCarbonic anhydrases inhibitorsGamma-aminobutyric acid A receptor antagonists +[5] 
TargetsKainic acid receptorCarbonic anhydrase IVGamma-aminobutyric acid A receptor +[8] 
Therapy Area/IndicationsContraceptionStress Disorders, Post-TraumaticAffective Disorders, Psychotic +[48] 
Global Approved IndicationsSeizuresMigraine DisordersEpilepsy
Approved Indications in ChinaSeizures
Original Approved Country/TerritoryUnited Kingdom
Original Approved Date1995/01/01
Country/TerritoryCzechiaBelgiumBulgaria +[41] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaApproved
Originator CompaniesJohnson & Johnson Innovative Medicine
China Registration ClassN/A

Develop Information

Active CompaniesJohnson & Johnson Innovative MedicineUniversity Of MinnesotaJanssen Pharmaceuticals Inc +[7] 
Inactive CompaniesJanssen-Ortho Inc., CanadaOrtho-Mcneil IncUniversity of Sao Paulo +[36] 
Active IndicationsStress Disorders, Post-TraumaticAlcoholismPediatric Obesity +[10] 
Inactive IndicationsContraceptionAffective Disorders, PsychoticMood Disorders +[38] 

Other Information

ATC CodeN03AX11
Related LinksN/A