Cyclosporine

环孢素

Report date: 2026/05/26 20:00:28
NME

Base Information

Drug NameCyclosporine
Drug Alias NameCyclosporin环孢霉素Cyclosporine A环孢菌素ACyclosporin A +[66] 
ClassificationSmall molecules > Molecular Glue
Mechanisms of ActionCalcineurin inhibitorsMitocliondrial permeability transition pore inhibitorsGlycoproteins inhibitors +[5] 
TargetsCalcineurinMitocliondrial permeability transition poreGlycoproteins +[4] 
Therapy Area/IndicationsRejection of organ transplantationPlaque psoriasisRejection of renal transplantation +[71] 
Global Approved IndicationsRejection of organ transplantationRejection of renal transplantationBone marrow transplant rejection +[7] 
Approved Indications in ChinaGraft vs Host DiseaseAutoimmune Diseases
Original Approved Country/TerritoryEU
Original Approved Date1983/01/01
Country/TerritoryCzechiaBelgiumBulgaria +[39] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaApproved
Originator CompaniesSun Pharmaceutical Industries LtdNovartis Pharma Ag
China Registration ClassN/A

Develop Information

Active CompaniesShenzhen Kangzhe Biotechnology Co LtdUniversity Of California San FranciscoOwl Therapeutics +[27] 
Inactive CompaniesHanmi Pharmaceutical Co LtdDana-Farber Cancer InstituteSanten Sas +[34] 
Active IndicationsRejection of organ transplantationRejection of renal transplantationRejection of lung transplantation +[30] 
Inactive IndicationsPlaque psoriasisInflammationNail Diseases +[41] 

Other Information

ATC CodeL04AD01S01XA18
Related LinksWikipediaDrugBankKEGG