Fluorouracil

氟尿嘧啶

Report date: 2026/05/26 20:00:28
NME

Base Information

Drug NameFluorouracil
Drug Alias Name氟脲嘧啶Fluorouracilum5-Fluorouracil氟二氧嘧啶Fluorouracilo +[13] 
ClassificationSmall molecules > Heterocyclic drugs
Mechanisms of ActionThymidylate synthase inhibitors
TargetsThymidylate synthase
Therapy Area/IndicationsEsophageal adenocarcinomaGastroesophageal Junction NeoplasmsLong Term Adverse Effects +[30] 
Global Approved IndicationsKeratosis, ActinicPancreatic NeoplasmsStomach Neoplasms +[6] 
Approved Indications in ChinaKeratosis, ActinicCarcinoma, Basal Cell
Original Approved Country/TerritoryUnited States
Original Approved Date1962/04/25
Country/TerritoryUnited StatesPuerto RicoPakistan +[10] 
CombinationsNo
Global Highest StatusApproved
Highest Status in ChinaApproved
Originator CompaniesSpectrum Pharmaceuticals Inc
China Registration ClassN/A

Develop Information

Active CompaniesCombined Military Hospital (CMH) institute of Medical Sciences Bahawalpur PakistanExtrovis AgWashington University School Of Medicine +[8] 
Inactive CompaniesSol-Gel Technologies LtdEncube Ethicals Pvt LtdFederal University Of Sao Paulo +[22] 
Active IndicationsGastroesophageal Junction NeoplasmsKeloidKeratosis, Actinic +[12] 
Inactive IndicationsEsophageal adenocarcinomaLong Term Adverse EffectsUterine Cervical Incompetence +[18] 

Other Information

ATC CodeL01BC02
Related LinksWikipediaDrugBankKEGG